Gout is a painful kind of inflammatory arthritis caused by the buildup of uric acid crystals in the joints. Due to food and lifestyle changes, the disorder has increased in prevalence and affects millions of people globally. Nonsteroidal anti-inflammatory medications (NSAIDs), colchicine, and other conventional therapies are ineffective and can have negative side effects. As a result, there is a rising demand for natural treatments for gout, such as sour cherry extract.
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Nature of Tart Cherry Extract
Tart cherries (Prunus cerasus), a fruit indigenous to Europe and western Asia, are the source of tart cherry extract. To create the extract, tart cherries are often processed to remove water and other substances, leaving behind a concentrated powder or liquid full of bioactive chemicals. Due to its antioxidant and anti-inflammatory qualities, tart cherry extract has recently gained popularity as a natural treatment for several ailments, most notably gout.
Health Benefits of Tart Cherry Extract
- Gout Management: Tart cherry extract, a significant gout risk factor, has been found to lessen the frequency of gout attacks by lowering serum uric acid levels. The extract decreases the possibility of uric acid crystal development in the joints by inhibiting the enzyme xanthine oxidase, which is in charge of producing uric acid.
- Anti-inflammatory Effects: The tart cherry extract’s anthocyanins have anti-inflammatory characteristics that may help reduce gout-related discomfort and inflammation. These substances prevent the synthesis of pro-inflammatory cytokines like tumor necrosis factor-alpha (TNF-alpha) and interleukin-1 (IL-1), essential for the onset and development of gout.
- Antioxidant Properties: Tart cherry extract demonstrates potent antioxidant activities that can assist in reducing inflammation and battling oxidative stress. Oxidative stress can boost the production of pro-inflammatory cytokines and encourage crystal formation, which has been linked to the etiology of gout.
Chemistry of Tart Cherry Extract
Anthocyanins, a group of water-soluble pigments that give the fruit its deep red color, are the main bioactive substances that provide tart cherry extract its health benefits. Cyanidin-3-glucoside and cyanidin-3-rutinoside are the highest concentrations of anthocyanins in tart cherries. In addition to anthocyanins, tart cherries include flavonoids and phenolic acids, which are beneficial substances. These elements support the extract’s general anti-inflammatory and antioxidant characteristics, essential to its potential advantages in gout treatment.
Physiological Mechanism of Action
Due to its effects on uric acid metabolism and inflammation, tart cherry extract’s physiological mechanism of action in gout treatment can be understood. Here are a few of the main mechanisms:
- Inhibition of Xanthine Oxidase: Studies have revealed that tart cherry extract inhibits xanthine oxidase, an enzyme that transforms hypoxanthine and xanthine into uric acid. The extract successfully lowers uric acid production by blocking this enzyme, reducing the possibility of joint crystal formation and relieving gout symptoms.
- Modulation of Inflammatory Pathways: Cyanidin-3-glucoside and cyanidin-3-rutinoside, two anthocyanins found in tart cherry extract, have anti-inflammatory activities. These substances have been demonstrated to prevent gout-related pro-inflammatory cytokines like interleukin-1 (IL-1) and tumor necrosis factor-alpha (TNF-) from being produced. This technique aids in reducing the condition’s pain and inflammation.
- Antioxidant Activity: Tart cherry extract’s antioxidant characteristics help explain why it works so well for treating gout. Due to the increased production of pro-inflammatory cytokines and exacerbation of inflammation, reactive oxygen species (ROS) created during oxidative stress can facilitate crystal formation. The tart cherry extract reduces oxidative stress by scavenging ROS, decreasing inflammation, and lowering the likelihood of crystal formation.
The physiological mechanism of action of tart cherry extract in gout treatment includes the inhibition of xanthine oxidase, the modification of inflammatory pathways, and antioxidant activity. These methods work together to lower uric acid levels, reduce discomfort and inflammation, and reduce the chance of developing joint crystals.
Optimal Dosage of Tart Cherry Extract
It is yet unknown exactly how much tart cherry extract is best to control gout. Numerous studies have shown positive effects at anthocyanin doses of 240–480 mg daily. Individual responses to supplementation may differ, so it’s crucial to remember that. Consult a healthcare provider before beginning a new supplement program.
Side Effects of Tart Cherry Extract
Tart cherry extract is usually considered safe when consumed per approved quantities. However, a few people might have moderate gastrointestinal side effects such as indigestion, diarrhea, or stomach pain. Typically, these symptoms are short-lived and go away on their own. It is recommended to stop using and seek medical advice if symptoms intensify or persist.
Potential Substance Interactions with Tart Cherry Extract
Although no substantial interactions between tart cherry extract and pharmaceuticals have been documented, it is essential to take some substances into account because of the possibility of interactions:
- Anticoagulants: Due to its potential antiplatelet properties, tart cherry extract may increase the risk of bleeding when used with anticoagulants like warfarin. Before using sour cherry extract, people who are taking anticoagulants should speak with their healthcare physician.
- Uric acid-lowering medications: Because tart cherry extract has been demonstrated to reduce uric acid levels, it may have additive effects when combined with uric acid-lowering medications like allopurinol or febuxostat. Healthcare professionals should carefully watch for any interactions between tart cherry extract and uric acid-lowering drugs in individuals.
Best Responsible Uses of Tart Cherry Extract
It is crucial to take a careful stance when considering using tart cherry extract as a nutritional supplement for gout management. For example, choose The Uric Acid Pill by Medicine Man Plant Co. as a trustworthy, premium supplier of tart cherry extract. This product provides one of the best sources of tart cherry extract in a synergistic and highly bioavailable formulation, assuring the best possible results for gout sufferers.
It is essential to choose a reliable supplier, follow the dosage instructions, and watch for adverse effects or potential drug combinations. As with any dietary supplement, seeking medical advice before beginning a new program is highly recommended.
Tart Cherry Extract: Conclusion
Tart cherry extract is a potent supplement that supports anti-inflammatory effects, antioxidant protection, improved sleep quality, pain relief, heart health, exercise recovery, blood sugar regulation, and cognitive function. Its comprehensive health benefits make it a valuable addition to many individuals’ health and wellness practices. While tart cherry extract offers these significant health benefits, it is essential to use it as part of a balanced diet and healthy lifestyle. Consulting with a healthcare professional before adding the tart cherry extract to your routine is advisable, especially for individuals with underlying health conditions or those taking medications.
References:
- Schumacher, H. R., Pullman-Mooar, S., Gupta, S. R., Dinnella, J. E., Kim, R., & McHugh, M. P. (2012). Randomized double-blind crossover study of the efficacy of a tart cherry juice blend in treatment of osteoarthritis (OA) of the knee. Osteoarthritis and Cartilage, 20(8), 830-836. https://doi.org/10.1016/j.joca.2013.05.009
- Kelley, D. S., Adkins, Y., & Laugero, K. D. (2018). A review of the health benefits of cherries. Nutrients, 10(3), 368. https://doi.org/10.3390/nu10030368
- Zhang, Y., Neogi, T., Chen, C., Chaisson, C., Hunter, D. J., & Choi, H. K. (2012). Cherry consumption and the risk of recurrent gout attacks. Arthritis & Rheumatism, 64(12), 4004-4011. https://doi.org/10.1002/art.34677
- Bell, P. G., Gaze, D. C., Davison, G. W., George, T. W., Scotter, M. J., & Howatson, G. (2014). Montmorency tart cherry (Prunus cerasus L.) concentrate lowers uric acid, independent of plasma cyanidin-3-O-glucosiderutinoside. Journal of Functional Foods, 11, 82-90. https://doi.org/10.1016/j.jff.2014.09.004
- Jacob, R. A., Spinozzi, G. M., Simon, V. A., Kelley, D. S., Prior, R. L., Hess-Pierce, B., & Kader, A. A. (2003). Consumption of cherries lowers plasma urate in healthy women. The Journal of Nutrition, 133(6), 1826-1829. https://doi.org/10.1093/jn/133.6.1826
Important Note: The information contained in this article is for general informational purposes only, and should not be construed as health or medical advice, nor is it intended to diagnose, prevent, treat, or cure any disease or health condition. Before embarking on any diet, fitness regimen, or program of nutritional supplementation, it is advisable to consult your healthcare professional in order to determine its safety and probable efficacy in terms of your individual state of health.
Regarding Nutritional Supplements Or Other Non-Prescription Health Products: If any nutritional supplements or other non-prescription health products are mentioned in the foregoing article, any claims or statements made about them have not been evaluated by the U.S. Food and Drug Administration, and such nutritional supplements or other health products are not intended to diagnose, treat, cure, or prevent any disease.
